Top pick
Our first pick is a full-spectrum CBD oil with 25 mg CBD per 1 mL. It ships with a third-party certificate of analysis (COA). The COA lists CBD, THC, and 12 other cannabinoids. THC stays at 0.3% or less, the federal limit for hemp. This format matches the dose range in the 2019 case series by Shannon et al., which used 25 mg to 175 mg per day.
full spectrum cbd vs isolate for panic attacks
Dosage
No health agency has set a CBD dose for anxiety. The FDA approved Epidiolex, a CBD drug, for seizures at 2.5 mg to 20 mg per kg per day. That dose does not carry over to anxiety.
Why CBD Makes My Anxiety Worse Sometimes
Start low
Start at 10 mg to 25 mg once daily. Take the oil with food. Hold the dose for 3 to 7 days. Then raise it by 5 mg. Stop at the dose that gives the result you want. Single doses in human trials were 150 mg, 300 mg, 400 mg, and 600 mg.
full spectrum cbd vs isolate for panic attacks
Timing
Oil held under the tongue enters the blood in 15 to 45 minutes. Effects last 4 to 6 hours. Capsules take 1 to 2 hours and last 6 to 8 hours.
Options
- Full-spectrum oil: 25 mg CBD per mL. THC up to 0.3%. Other cannabinoids present.
- Broad-spectrum oil: 50 mg CBD per mL. THC removed. Lab panel reads 0.0% THC.
- CBD isolate: 1000 mg in a 30 mL bottle, 16.6 mg per drop. No THC. No other cannabinoids.
Reviews
Reviews of CBD for anxiety are mixed. A 2015 review of 49 studies found evidence for CBD in social anxiety disorder, panic disorder, and obsessive-compulsive disorder. Most of those studies used animals. Human trials are small. In the 2019 case series, 79 patients took 25 mg to 175 mg per day. 72 of 79 reported less anxiety in the first month. There was no placebo group. In placebo-controlled trials, the placebo group improves by 30% or more, so self-reports are weak evidence.
Buy from a seller that posts batch COAs. Check the harvest date and the cannabinoid panel. Avoid labels with no batch number.
Safety
CBD blocks CYP3A4 and CYP2C19 enzymes. It can raise blood levels of warfarin, clobazam, and some SSRIs. The Epidiolex label lists liver injury as a risk. Talk to a doctor before use if you take a prescription drug or have liver disease.